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Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C | ACS Medicinal Chemistry Letters
Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C | ACS Medicinal Chemistry Letters

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) | ACS Medicinal Chemistry Letters
Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) | ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters: Volume 11, Issue 5
ACS Medicinal Chemistry Letters: Volume 11, Issue 5

Featured Letter in ACS Medicinal Chemistry Letters – NITSCHE LAB
Featured Letter in ACS Medicinal Chemistry Letters – NITSCHE LAB

Development of Chimeric Molecules That Degrade the Estrogen Receptor Using Decoy Oligonucleotide Ligands | ACS Medicinal Chemistry Letters
Development of Chimeric Molecules That Degrade the Estrogen Receptor Using Decoy Oligonucleotide Ligands | ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters | Ahead of Print
ACS Medicinal Chemistry Letters | Ahead of Print

Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines | ACS Medicinal Chemistry Letters
Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines | ACS Medicinal Chemistry Letters

Relevance of the Trillion-Sized Chemical Space “eXplore” as a Source for Drug Discovery | ACS Medicinal Chemistry Letters
Relevance of the Trillion-Sized Chemical Space “eXplore” as a Source for Drug Discovery | ACS Medicinal Chemistry Letters

Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design | ACS Medicinal Chemistry Letters
Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design | ACS Medicinal Chemistry Letters

Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors | ACS Medicinal Chemistry Letters
Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors | ACS Medicinal Chemistry Letters

Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition | ACS Medicinal Chemistry Letters
Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition | ACS Medicinal Chemistry Letters

Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors | ACS Medicinal Chemistry Letters
Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors | ACS Medicinal Chemistry Letters

Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448) | ACS Medicinal Chemistry Letters
Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448) | ACS Medicinal Chemistry Letters

Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors | ACS Medicinal Chemistry Letters
Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors | ACS Medicinal Chemistry Letters

Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4 | ACS Medicinal Chemistry Letters
Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4 | ACS Medicinal Chemistry Letters

Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists | ACS Medicinal Chemistry Letters
Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists | ACS Medicinal Chemistry Letters

Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833 | ACS Medicinal Chemistry Letters
Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833 | ACS Medicinal Chemistry Letters

Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series | ACS Medicinal Chemistry Letters
Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series | ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters | Vol 11, No 11
ACS Medicinal Chemistry Letters | Vol 11, No 11

Systematic Study of Effects of Structural Modifications on the Aqueous Solubility of Drug-like Molecules | ACS Medicinal Chemistry Letters
Systematic Study of Effects of Structural Modifications on the Aqueous Solubility of Drug-like Molecules | ACS Medicinal Chemistry Letters